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Pathogenesis of insulin resistance

  • M. Kalafati (Maastricht) schreef:

    Thank you for your nice presentation! Very interesting results. I was wondering could it be that physical activity in the afternoon or the evening is associated with less stress? Assuming that these individuals would go to exercise after work maybe the feel more “relaxed” and purposeful as you mention.

    • schreef:

      Thank you! Yes, as briefly mentioned in the discussion, it may be that ‘afternoon’ and ‘evening’ active participants engage in exercise purposely. This could very well also be associated with less stress. We plan on checking questionnaire derived physical activity data to see if there are differences in work-related and/or leisure physical activities. Since work-related activity has been associated with adverse health outcomes this may help to explain our findings.

  • S. Kooijman (Leiden) schreef:

    Do you have any data on chronotype of the individuals? Just wondering if this effects on homa-ir is a direct effect, or more indirect via, for example, a shift in their overall behavior.

    I assume the homa-IR measurements are taken during the day, it’s interesting to see that the effects of late activity remains present for quite some time… 🙂

    • schreef:

      Hi Sander,
      Unfortunately, we don’t have chronotype data in the base line measurements of the NEO study. However, we are collecting, (or actually, would’ve been if it wasn’t for COVID) data on chronotype in the second wave of measurements in this population.

  • bertjanpottervanloon schreef:

    Nice paper ! Congrats !

    Bad news for me, because I am a morning runner; I mean running at >10 MET for 30 min several times a week; in the morning one burns more fat, because of the fasting state; I always thought that would offer some protection ( more weight loss ; and thus decrease of IR).

    Your study was on > 3 MET; did you see any differences in the subgroup with sunstantially more MET activity ?

    • schreef:

      Hi, thank you! Well, if indeed the ‘morning’ active people in this population would all be running at high intensity, these results are not what you expect. However, in over 85% participants in this population VPA is less than 1% of total daily activities. We have not (yet) performed this analysis based on vigorous activity (say >6 MET). However, we have done so based on total PAEE. There, we did not observe any differences between the morning, afternoon, or evening groups.

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