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Pathogenesis of insulin resistance

  • JF. Harmsen (Maastricht) schreef:

    Hello visitor of my abstract!
    I would be happy to discuss my data with you 🙂

    • S. Kooijman (Leiden) schreef:

      I’m a bit puzzled. If there is more insulin-resistance in during misalignment, why would the muscle ‘invest’ energy in FA elongation? Any thoughts on that?

      • JF. Harmsen (Maastricht) schreef:

        Great question. Would you think that fatty acid (FA) elongation is an energy investment? So far, we thought of it as a way to store the excessive energy (higher plasma FA upon misalignment in the new behavioral morning). For now, I know too little about FA elongation. So you would argue that it would imply a notable energy investment?

        • S. Kooijman (Leiden) schreef:

          As far as I know, you need NADPH for FA elongation, which is derived from the pentose-phosphate pathway, meaning that you actually need glycolysis. That seems counterintuitive in the context of insulin-resistance, but I’m also not an expert…

          • JF. Harmsen (Maastricht) schreef:

            Thanks Sander. I will look into this. We did not approach this finding from your perspective yet, we only saw the connection that insulin resistance is often associated with greater abundancy in longer fatty acid species in skeletal muscle…

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