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Pathogenesis of insulin resistance

  • Rinke.stienstra@wur.nl schreef:

    Very nice work! It seems that LD number rapidly increases in athletes and not in T2DM. How would you explain this difference?
    LD numbers seem to reach a plateau after about 10 hours, at least in the athletes. What would determine the number of LDs that can be formed in the cells? Availability of the LD machinery? Or is there a certain balance between synthesis and turnover of the LD droplets that is reached after 10 hours?

    • A. Gemmink (Maastricht) schreef:

      Thanks for your question Rinke. This difference may be explained by the better capacity of athletes to create new LDs than T2DM. In skeletal muscle biopsies we see that athletes have more and smaller LDs than T2DM who were matched for total muscle lipid content. For the plateau, I indeed think that at that moment there is a balance between synthesis and breakdown for fatty acid oxidation. This data is still preliminary, I don’t have data yet on mechanisms that can support the preliminary conclusions.

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