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Gastro-intestinal and & liver biology

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  1. JF. Harmsen (Maastricht) 26 november 2020 bij 18:06- Antwoorden

    Hey Kelly, nice presentation 🙂 a few questions: How many different bacteria species did you detect? How do you explain the correlations in skeletal muscle mitochondrial oxidative capacity with certain gut bacteria (if I understood it correctly)? I don’t have an idea why these should be correlated. Oxidative capacity did then also not change from pre to post, right?

    • K. Jardon (Maastricht) 27 november 2020 bij 15:28- Antwoorden

      Thank you Frieder! To start with your last remark: results of the this 12-week polyphenol supplementation on skeletal muscle oxidative capacity have been published before (doi: 10.3945/ajcn.115.122937). In this analysis, it was found that this combined polyphenol supplementation significantly increased skeletal muscle oxidative capacity and fat oxidation, without an effect on tissue specific insulin sensitivity. Here, we have used the same data to do some additional analysis related to the gut microbiome. These datasets are quite extensive, with on genus level 100+ different bacteria present. Of these, the genera shown in the slides correlated to changes in skeletal muscle oxidative capacity, but not to other metabolic outcomes. We can only speculate about the potential mechanisms relating baseline gut microbiota to changes in metabolic outcomes, but it may related to the functionality of of the gut microbiome, e.g. SCFA production, bile acid composition and inflammatory markers. Microbiome -related research is complex to interpret, but more and more findings are being published indicating a predictive capacity for the baseline microbial profile in (dietary) interventions. This may hint towards the need for more personalized nutritional strategies!

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