Thank you! How about the difference between those with and those without stress/psychiatric problems?
THanks for your question! A previous colleague reported a significant association between HairF and depressive symptoms (IDS score) ( Gerritsen & Staufenbiel et al, 2018). Not all other large cohorts can repeat this however.
This is a nice systematic review on the relation between depressive symptoms and hair glucocorticoids https://www.sciencedirect.com/science/article/abs/pii/S0149763419309443
Thank you. I can not read the complete article from home but saved it to look it up at work.
Of course I still wonder if the effect om BMI/WC (glucose) is caused by the higher cortisol. That is difficult to investigate, I think. But my theory would be that there is common cause and that common cause could be depression. So I wonder if your group of people without depression show the same results as the total group
Yes, I agree. It is of course not yet clear that the relation cortisol/BMI/WC is causal. However, the cross-sectional relation between long-term cortisol and depression is much more inconsistent than cortisol/BMI ( which is now quite well established). Moreover, our results can be a first indication for causality as we demonstrate that cortisol is actually predictive for weight gain/WC change ( which was not the case for depressive symptoms).
Also, the groups with depression and without depression did not differ so much, if there was any relation it was for cortisol – depressive symptoms on a continuous scale.
However, indeed it is going to be challenging to prove true causality ( but this is something we are working on for the future!:) )