Towards a GMP-Compliant Protocol for the Differentiation of Human Pluripotent Stem Cells to β-like Cells for the Treatment of Type 1 Diabetes

B. Rajaei (Leiden)

Type 2 diabetes in South Asians compared to white Caucasians: higher risk and earlier development of major cardiovascular events irrespective of the presence and degree of retinopathy. Results from The HinDu The Hague Diabetes Study

J. van Niel (Den Haag)

Fully Closed Loop Glucose Control with a Bihormonal Artificial Pancreas in Adults with Type 1 Diabetes: an Outpatient, Randomized, Crossover Trial

H. Blauw (Amsterdam)

Hair glucocorticoids, obesity and fasting blood glucose levels: results from a 3 year longitudinal study

E. van der Valk (Rotterdam)

Effects of liraglutide treatment in genetic obesity

M. Welling (Rotterdam)

Long-term glucocorticoids are associated with increased odds of metabolic syndrome after a combined lifestyle intervention

M. Mohseni (Rotterdam)

Degree of sensory loss predicts the risk of foot ulceration in patients with diabetes mellitus

W.D. Rinkel (Utrecht)

Long term follow up of low dose metformin in prediabetic individuals: an interim analysis

Oscar

Monoclonal alpha-cells display a heterogenous calcium response when subjected to glucose stimulation

F.W.J. Boot (Leiden)

The relation between insulin resistance and risk of cardiovascular events, vascular interventions and all-cause mortality in people with type 1 diabetes: results from the UCC-SMART cohort study

M.A.G. Helmink (Utrecht)

Large-scale electron microscopy database for human type 1 diabetes

P. de Boer (Groningen)

Accelerometer-measured sedentary time and physical activity and incident cardiovascular disease: The Maastricht Study

W. Li (Maastricht)

Diazoxide pre-treatment prevents glucotoxicity-induced beta-cell dysfunction and death in isolated human islets

M. Paz-Barba (Leiden)

Evaluating glycaemic control of patients with type 1 diabetes mellitus in a Dutch hospital: a cross-sectional real-world database study using electronic medical records

S. van Eeghen (Alkmaar)

Effects of gestational hyperglycemia on placental function in a mouse model for lean gestational diabetes mellitus

A.J.C. Tol (Groningen)

The use of GLP-1 agonists and SGLT2 inhibitors during pregnancy and lactation: a systematic review of the evidence

D.R.P. Muller (Amsterdam)

Long-RNA sequencing and ribosome profiling reveal novel candidate autoantigens in type 1 diabetes

S. Thomaidou (Leiden)

Modest increase in hepatic lipid content in early postnatal female offspring of non-obese mice with gestational diabetes mellitus

K. Hribar (Groningen)

Towards a comparative assessment score for beta cell replacement therapy and automated insulin delivery: updating the Igls Criteria

Cyril

Towards a GMP-Compliant Protocol for the Differentiation of Human Pluripotent Stem Cells to β-like Cells for the Treatment of Type 1 Diabetes

B. Rajaei (Leiden)

Microglial insulin signalling plays a role in the progression of dietary-induced obesity

I.V. Milanova (Amsterdam)

Different insulin sensitivity of plasma metabolites in a two-step hyperinsulinemic-euglycemic clamp study

W. Wang (Leiden)

Kidney hemodynamic profile and systemic vascular function in adults with type 2 diabetes: analysis of four clinical trials

A.C. Hesp (Amsterdam)

Body fat at adolescence and early changes in atherogenic metabolomic measures during young adulthood

I. Verkouter (Leiden)

Dapagliflozin is cost effective compared to DPP4 inhibitors in the treatment of type 2 diabetes mellitus in the Netherlands

N. van der Linden (Den Haag)

Serum magnesium is an independent predictor of macrovascular and microvascular complications in type 2 diabetes

L.J. Oost (Nijmegen)

Therapeutic efficiency of lowering branched-chain amino acid levels in patients with type 2 diabetes using sodium-phenylbutyrate: a randomized placebo-controlled clinical intervention study

F. Vanweert (Maastricht)

Timing of physical activity may impact insulin resistance

J.H.P.M. van der Velde (Leiden)

PCr/ATP ratio’s measured with 31P-MRS do not correlate with atrial cardiac mitochondrial function

T. van de Weijer (Maastricht)

The glycolytic by-product methylglyoxal is present in immune cells and may affect their recruitment

X. Zhang (Maastricht)

Monogenic Diabetes: the Impact of Making the Right Diagnosis

K. van der Tuin (Leiden)

The assessment of intrahepatic islet transplantation using exendin PET imaging

T.J.P. Jansen (Nijmegen)

Integrative bioinformatic and laboratory approaches shed new light on the molecular mechanisms underlying beta cell identity loss in T1D

A. Muñoz García (Leiden)

Monitoring liver glucose metabolism with deuterium metabolic imaging

A. Gursan (Utrecht)

Impact of differences in white blood cell composition in insulin resistant individuals on whole blood transcriptome analysis and interpretation – The CODAM study

M. Kalafati (Maastricht)

A Complex System Approach to the Assessment of Homeostasis Loss in Type 2 Diabetes

J.L. Flores-Guerrero (Groningen)

PPARdelta in hypothalamic microglial controls glucose metabolism and insulin sensitivity

F. Cázarez-Márquez (Amsterdam)

The gut microbiome in long-standing type 1 diabetes

J.I.P. van Heck (Nijmegen)

Microbiological safety in islet transplantation: a 13-year retrospective analysis

A. Steffen (Leiden)

Type 2 diabetes in South Asians compared to white Caucasians: higher risk and earlier development of major cardiovascular events irrespective of the presence and degree of retinopathy. Results from The HinDu The Hague Diabetes Study

J. van Niel (Den Haag)

12-week combined polyphenol supplementation: indications for sex-specific differences in gut microbiome-host metabolism interaction in individuals with overweight and obesity

K. Jardon (Maastricht)

Predicting liver fat content using routinely measured predictors: a development study

S.C. Boone (Leiden)

Pancreatic uptake of radiolabeled exendin as a measure of beta cell mass in T2DM before and after bariatric surgery

L.N. Deden (Arnhem)

The Associations of Leptin and Adiponectin with the Metabolic Syndrome in an Indonesian and a Dutch Population

F. Sigit (Leiden)

Growth in children prior to diagnosis of juvenile type 1 diabetes: A systematic review

Y. Kahn (Brussel)

Genetically-influenced lower TG levels on top of genetically-influenced lower LDL-C levels are associated with an improved lipoprotein profile

D. Ibi (Leiden)

Liraglutide treatment improves immune gene expression in blood of overweight type 2 diabetes patients of South Asian descent

M.E. Straat (Leiden)

Timing of physical activity in relation to body weight and metabolic health in sedentary older people: a cross-sectional and prospective analysis

G. Albalak (Leiden)

Effects of 12 different heel rocker designs, configurated with different rocker radii, apex positions and apex angles, on plantar pressure

A. Malki (Groningen)

Sansevieria trifasciata leaf extract protects pancreatic beta-cells against streptozotocin-induced cell death via the Nf-kB pathway

C.W. Hoornenborg (Groningen)

Carnitine supplementation improves insulin sensitivity and skeletal muscle acetylcarnitine formation in type 2 diabetes patients

Y.M.H. Bruls (Maastricht)

Complement factor D (adipsin) is positively associated with cfPWV in individuals with T2D: The Maastricht study

S. Jin (Maastricht)

Dairy product consumption and incident prediabetes in Dutch middle-aged adults: The Hoorn Studies

I.A.L. Slurink (Tilburg)

Dietary protein composition and renal outcome: a prospective study in the Diabetes and Lifestyle Cohort Twente (DIALECT)

M.M. Oosterwijk (Almelo)

Social determinants of health and complications among young adults with type 2 diabetes in an urban population

E.A. Nieuwenhuijse (Den Haag)

111In-exendin SPECT imaging suggests presence of residual beta cells in patients with longstanding type 1 diabetes

M. Boss (Nijmegen)

Human IAPP drives painful diabetic peripheral neuropathy

M.M.H. Asiri (Utrecht)

Circadian control of brown adipose tissue activity by glucocorticoids

S. Kooijman (Leiden)

The effectiveness of at-home foot temperature monitoring in reducing the incidence of ulcer recurrence in people with diabetes: a multicentre randomized controlled trial (DIATEMP)

S.A. Bus (Amsterdam)

Increased stress, weight gain and less exercise in relation to glycaemic control in people with type 1 and type 2 diabetes during the COVID-19 pandemic

Merel

Development of a prediction model for foot ulcer recurrence in people with diabetes using easy-to-obtain clinical variables

J.J. van Netten (Amsterdam) 

Relationship between de novo lipogenesis and serum sex hormone-binding globulin in humans

P.I.H.G. Simons (Maastricht)

Circadian misalignment disturbs the lipidome in human skeletal muscle

JF. Harmsen (Maastricht)

Polymorphisms in glyoxalase I gene are not associated with glyoxalase I expression or markers of methylglyoxal stress: The CODAM study

K. Maasen (Maastricht)

Sedentary time and physical activity are associated with endothelial dysfunction and low-grade inflammation – the Maastricht Study

E.J. Vandercappellen (Maastricht)

Higher daily glucose variability is associated with worse cognitive performance – The Maastricht Study

Y.D. Foreman (Maastricht) 

Glucose regulation beyond HbA1c in Type 2 Diabetes treated with insulin

N. den Braber (Almelo)

Associations of ultra-processed food and its underlying consumption patterns with incident Type 2 Diabetes: the Lifelines cohort study

M. Duan (Groningen)

Sexual dimorphism in body weight loss, improvements in cardiometabolic risk factors and maintenance of beneficial effects 6 months after a low-calorie diet: results from the DiOGenes trial

I. Trouwborst (Maastricht)

Cytokine output of adipocyte-iNKT cell interplay is skewed by a lipid-rich microenvironment

I. Morris (Utrecht)

Association between dietary carbohydrates and liver fat content: the NEO study

E. Winters-van Eekelen (Leiden)

Fully Closed Loop Glucose Control with a Bihormonal Artificial Pancreas in Adults with Type 1 Diabetes: an Outpatient, Randomized, Crossover Trial

H. Blauw (Amsterdam)

Effects of macronutrient intake in obesity: a meta-analysis of low-carbohydrate and low-fat diets on markers of the metabolic syndrome

A.E.M Willems (Groningen/Leeuwarden)

Feasibility and Reproducibility of the Muscle Sound® Technique in a Morbidly Obesity Population: MUST-MOP Study

D. Sizoo (Leeuwarden)

A novel microscopy tool to study in vitro lipid droplet dynamics in human primary myotubes

A. Gemmink (Maastricht)

Effects of diabetes mellitus on fibrin clot structure and mechanics in a model of acute neutrophil extracellular traps (NETs) formation

J.J. de Vries (Rotterdam)

Evaluation of adherence to medication by LC-MS/MS urine testing and relation with clinical outcomes in type 2 diabetes: an analysis in the Diabetes and Lifestyle Cohort Twente

J.M. Beernink (Almelo) 

Moderate hypoglycaemia affects cognitive function in people with diabetes, irrespective of diabetes type, level of glucose control or hypoglycaemic awareness

C.E.M. Verhulst (Nijmegen)

A novel microscopy tool to study in vitro lipid droplet dynamics in human primary myotubes

A. Gemmink (Maastricht)

Circadian misalignment disturbs the lipidome in human skeletal muscle

JF. Harmsen (Maastricht)

Impact of differences in white blood cell composition in insulin resistant individuals on whole blood transcriptome analysis and interpretation – The CODAM study

M. Kalafati (Maastricht)

The glycolytic by-product methylglyoxal is present in immune cells and may affect their recruitment

X. Zhang (Maastricht)

Timing of physical activity may impact insulin resistance

J.H.P.M. van der Velde (Leiden)

Therapeutic efficiency of lowering branched-chain amino acid levels in patients with type 2 diabetes using sodium-phenylbutyrate: a randomized placebo-controlled clinical intervention study

F. Vanweert (Maastricht)

Different insulin sensitivity of plasma metabolites in a two-step hyperinsulinemic-euglycemic clamp study

W. Wang (Leiden)

Cytokine output of adipocyte-iNKT cell interplay is skewed by a lipid-rich microenvironment

I. Morris (Utrecht)

Circadian control of brown adipose tissue activity by glucocorticoids

S. Kooijman (Leiden)

Relationship between de novo lipogenesis and serum sex hormone-binding globulin in humans

P.I.H.G. Simons (Maastricht)

12-week combined polyphenol supplementation: indications for sex-specific differences in gut microbiome-host metabolism interaction in individuals with overweight and obesity

K. Jardon (Maastricht)

Modest increase in hepatic lipid content in early postnatal female offspring of non-obese mice with gestational diabetes mellitus

K. Hribar (Groningen)

Long term follow up of low dose metformin in prediabetic individuals: an interim analysis

Oscar

Kidney hemodynamic profile and systemic vascular function in adults with type 2 diabetes: analysis of four clinical trials

A.C. Hesp (Amsterdam)

Body fat at adolescence and early changes in atherogenic metabolomic measures during young adulthood

I. Verkouter (Leiden)

Serum magnesium is an independent predictor of macrovascular and microvascular complications in type 2 diabetes

L.J. Oost (Nijmegen)

PCr/ATP ratio’s measured with 31P-MRS do not correlate with atrial cardiac mitochondrial function

T. van de Weijer (Maastricht)

Type 2 diabetes in South Asians compared to white Caucasians: higher risk and earlier development of major cardiovascular events irrespective of the presence and degree of retinopathy. Results from The HinDu The Hague Diabetes Study

J. van Niel (Den Haag)

Genetically-influenced lower TG levels on top of genetically-influenced lower LDL-C levels are associated with an improved lipoprotein profile

D. Ibi (Leiden)

Liraglutide treatment improves immune gene expression in blood of overweight type 2 diabetes patients of South Asian descent

M.E. Straat (Leiden)

Effects of diabetes mellitus on fibrin clot structure and mechanics in a model of acute neutrophil extracellular traps (NETs) formation

J.J. de Vries (Rotterdam)

111In-exendin SPECT imaging suggests presence of residual beta cells in patients with longstanding type 1 diabetes

M. Boss (Nijmegen)

Sansevieria trifasciata leaf extract protects pancreatic beta-cells against streptozotocin-induced cell death via the Nf-kB pathway

C.W. Hoornenborg (Groningen)

Pancreatic uptake of radiolabeled exendin as a measure of beta cell mass in T2DM before and after bariatric surgery

L.N. Deden (Arnhem)

Integrative bioinformatic and laboratory approaches shed new light on the molecular mechanisms underlying beta cell identity loss in T1D

A. Muñoz García (Leiden)

Towards a comparative assessment score for beta cell replacement therapy and automated insulin delivery: updating the Igls Criteria

Cyril

Long-RNA sequencing and ribosome profiling reveal novel candidate autoantigens in type 1 diabetes

S. Thomaidou (Leiden)

Diazoxide pre-treatment prevents glucotoxicity-induced beta-cell dysfunction and death in isolated human islets

M. Paz-Barba (Leiden)

Large-scale electron microscopy database for human type 1 diabetes

P. de Boer (Groningen)

Monoclonal alpha-cells display a heterogenous calcium response when subjected to glucose stimulation

F.W.J. Boot (Leiden)

Microglial insulin signalling plays a role in the progression of dietary-induced obesity

I.V. Milanova (Amsterdam)

PPARdelta in hypothalamic microglial controls glucose metabolism and insulin sensitivity

F. Cázarez-Márquez (Amsterdam)

Higher daily glucose variability is associated with worse cognitive performance – The Maastricht Study

Y.D. Foreman (Maastricht) 

Moderate hypoglycaemia affects cognitive function in people with diabetes, irrespective of diabetes type, level of glucose control or hypoglycaemic awareness

C.E.M. Verhulst (Nijmegen)

Long-term glucocorticoids are associated with increased odds of metabolic syndrome after a combined lifestyle intervention

M. Mohseni (Rotterdam)

Accelerometer-measured sedentary time and physical activity and incident cardiovascular disease: The Maastricht Study

W. Li (Maastricht)

Carnitine supplementation improves insulin sensitivity and skeletal muscle acetylcarnitine formation in type 2 diabetes patients

Y.M.H. Bruls (Maastricht)

Dietary protein composition and renal outcome: a prospective study in the Diabetes and Lifestyle Cohort Twente (DIALECT)

M.M. Oosterwijk (Almelo)

Sedentary time and physical activity are associated with endothelial dysfunction and low-grade inflammation – the Maastricht Study

E.J. Vandercappellen (Maastricht)

Associations of ultra-processed food and its underlying consumption patterns with incident Type 2 Diabetes: the Lifelines cohort study

M. Duan (Groningen)

Sexual dimorphism in body weight loss, improvements in cardiometabolic risk factors and maintenance of beneficial effects 6 months after a low-calorie diet: results from the DiOGenes trial

I. Trouwborst (Maastricht)

Association between dietary carbohydrates and liver fat content: the NEO study

E. Winters-van Eekelen (Leiden)

Effects of macronutrient intake in obesity: a meta-analysis of low-carbohydrate and low-fat diets on markers of the metabolic syndrome

A.E.M Willems (Groningen/Leeuwarden)

Evaluation of adherence to medication by LC-MS/MS urine testing and relation with clinical outcomes in type 2 diabetes: an analysis in the Diabetes and Lifestyle Cohort Twente

J.M. Beernink (Almelo) 

Feasibility and Reproducibility of the Muscle Sound® Technique in a Morbidly Obesity Population: MUST-MOP Study

D. Sizoo (Leeuwarden)

Fully Closed Loop Glucose Control with a Bihormonal Artificial Pancreas in Adults with Type 1 Diabetes: an Outpatient, Randomized, Crossover Trial

H. Blauw (Amsterdam)

Glucose regulation beyond HbA1c in Type 2 Diabetes treated with insulin

N. den Braber (Almelo)

Development of a prediction model for foot ulcer recurrence in people with diabetes using easy-to-obtain clinical variables

J.J. van Netten (Amsterdam) 

Increased stress, weight gain and less exercise in relation to glycaemic control in people with type 1 and type 2 diabetes during the COVID-19 pandemic

Merel

Timing of physical activity in relation to body weight and metabolic health in sedentary older people: a cross-sectional and prospective analysis

G. Albalak (Leiden)

The assessment of intrahepatic islet transplantation using exendin PET imaging

T.J.P. Jansen (Nijmegen)

Monogenic Diabetes: the Impact of Making the Right Diagnosis

K. van der Tuin (Leiden)

Dapagliflozin is cost effective compared to DPP4 inhibitors in the treatment of type 2 diabetes mellitus in the Netherlands

N. van der Linden (Den Haag)

Evaluating glycaemic control of patients with type 1 diabetes mellitus in a Dutch hospital: a cross-sectional real-world database study using electronic medical records

S. van Eeghen (Alkmaar)

Degree of sensory loss predicts the risk of foot ulceration in patients with diabetes mellitus

W.D. Rinkel (Utrecht)

Effects of liraglutide treatment in genetic obesity

M. Welling (Rotterdam)

Hair glucocorticoids, obesity and fasting blood glucose levels: results from a 3 year longitudinal study

E. van der Valk (Rotterdam)

Polymorphisms in glyoxalase I gene are not associated with glyoxalase I expression or markers of methylglyoxal stress: The CODAM study

K. Maasen (Maastricht)

The effectiveness of at-home foot temperature monitoring in reducing the incidence of ulcer recurrence in people with diabetes: a multicentre randomized controlled trial (DIATEMP)

S.A. Bus (Amsterdam)

Human IAPP drives painful diabetic peripheral neuropathy

M.M.H. Asiri (Utrecht)

Social determinants of health and complications among young adults with type 2 diabetes in an urban population

E.A. Nieuwenhuijse (Den Haag)

Dairy product consumption and incident prediabetes in Dutch middle-aged adults: The Hoorn Studies

I.A.L. Slurink (Tilburg)

Complement factor D (adipsin) is positively associated with cfPWV in individuals with T2D: The Maastricht study

S. Jin (Maastricht)

Effects of 12 different heel rocker designs, configurated with different rocker radii, apex positions and apex angles, on plantar pressure

A. Malki (Groningen)

Growth in children prior to diagnosis of juvenile type 1 diabetes: A systematic review

Y. Kahn (Brussel)

The Associations of Leptin and Adiponectin with the Metabolic Syndrome in an Indonesian and a Dutch Population

F. Sigit (Leiden)

Predicting liver fat content using routinely measured predictors: a development study

S.C. Boone (Leiden)

Microbiological safety in islet transplantation: a 13-year retrospective analysis

A. Steffen (Leiden)

The gut microbiome in long-standing type 1 diabetes

J.I.P. van Heck (Nijmegen)

A Complex System Approach to the Assessment of Homeostasis Loss in Type 2 Diabetes

J.L. Flores-Guerrero (Groningen)

Monitoring liver glucose metabolism with deuterium metabolic imaging

A. Gursan (Utrecht)

Towards a GMP-Compliant Protocol for the Differentiation of Human Pluripotent Stem Cells to β-like Cells for the Treatment of Type 1 Diabetes

B. Rajaei (Leiden)

The use of GLP-1 agonists and SGLT2 inhibitors during pregnancy and lactation: a systematic review of the evidence

D.R.P. Muller (Amsterdam)

Effects of gestational hyperglycemia on placental function in a mouse model for lean gestational diabetes mellitus

A.J.C. Tol (Groningen)

The relation between insulin resistance and risk of cardiovascular events, vascular interventions and all-cause mortality in people with type 1 diabetes: results from the UCC-SMART cohort study

M.A.G. Helmink (Utrecht)